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患有慢性脏病的患者中与缩症相关的危险因素:系统性审查和元分析
Kaili Jin1, Xiaoyan Li1, Yiqin Ma1
1School of Nursing, Zhejiang Chinese Medical University, Hangzhou, China.
Journal of cachexia, sarcopenia and muscle
|December 29, 2025
概括
慢性脏病 (CKD) 患者的肉症与糖尿病和BMI等因素有关. 识别这些风险因素对于早期干预和有效的治疗策略在CKD群体中至关重要.
科学领域:
- 老年学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肌肉生理学 肌肉生理学
背景情况:
- 肌肉质量和功能与年龄相关的下降,是慢性病 (CKD) 的高度流行.
- 了解慢性病患者的肉类的危险因素对于及时的临床干预至关重要.
研究的目的:
- 在被诊断为慢性病的患者中,系统地识别和分析与肉类相关的临床和流行病学风险因素.
- 在CKD的不同阶段,提供影响肉症发展的因素的全面概述.
主要方法:
- 在多个数据库 (PubMed,Embase,Web of Science等) 进行了系统的文献搜索. 最长时间为2025年5月.
- 包含的研究报告了慢性病患者的肉类的危险因素;数据是独立提取的.
- 计算了几率比率 (OR),并进行了灵敏度和子组分析.
主要成果:
- 58项与15425名参与者的研究显示,糖尿病是显著的风险因素 (OR=1.96).
- 较高的BMI是保护性的 (OR=0.76).
- 具体因素因CKD阶段而异:NDD-CKD (老年,糖尿病,CRP增加),HD (糖尿病,体内蛋白质) 和RTR (更长时间的透析复古).
结论:
- 慢性病患者的肉类是多因素的,受各种风险因素的影响.
- 了解这些因素有助于识别有针对性的预防和治疗的高风险个体.
- 优先考虑可修改的风险因素对于改善CKD中萨尔科佩尼亚管理至关重要.
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