接触热和冷引起潜力的规范值.
Yoshnee Foolchand1, Avgustina Kuzminova2, Marc-Henri Louis1,2
1Faculty of Medicine, Université Catholique de Louvain, Brussels, Belgium.
European journal of pain (London, England)
|December 29, 2025
概括
本研究确定了健康成年人接触热和冷引起潜能 (CHEP/CEP) 的规范值. 这些参考值有助于诊断小纤维神经病变和脊柱体道功能障碍.
科学领域:
- 神经科学是一个神经科学.
- 临床电生理学 临床电生理学
- 感官生理学 感官生理学
背景情况:
- 评估小纤维神经病变 (SFN) 和脊柱体管 (STT) 功能障碍需要可靠的神经生理学工具.
- 接触热引起的电位 (CHEP) 和冷引起的电位 (CEP) 提供了小纤维功能的客观测量.
- 建立规范性数据对于临床应用至关重要.
研究的目的:
- 在不同年龄组的健康成年人中确定CHEP和CEP的规范值.
- 为评估SFN和STT功能提供参考数据集.
- 为了比较上肢和下肢之间以及跨年龄组的CHEP和CEP参数.
主要方法:
- 健康的参与者 (n=80,年龄26-75) 接受了热定量感官测试和感官神经传导研究.
- 从前臂和脚部使用接触热刺激器 (60°C热,10°C冷,200分钟持续时间) 记录了CHEP和CEP.
- 计算了年龄分组的描述性统计数据,并将结果与年龄组,刺激地点和性别进行了比较.
主要成果:
- 在所有年龄段,上肢CEP的检测率高 (>90%).
- 对于CHEP和CEP,N2P2幅度在上肢与下肢相比较大 (p<0.05).
- 对于CHEP和CEP (p<0.01),N2P2幅度随着年龄的增长而下降,而延迟时间保持一致.
结论:
- 成功建立了CHEP和CEP的规范性数据,支持它们的临床整合.
- CHEP和CEP是客观的,非侵入性的工具,用于评估小光纤和STT功能.
- 与年龄相关的幅度下降,特别是在脚部,强调了年龄相匹配的规范值的重要性.
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