终端呼吸障碍的临床特征和治疗结果:一个多中心队列研究
Satoru Miwa1, Masanori Mori2, Kengo Imai1
1Seirei Mikatahara General Hospital, Seirei Hospice, Hamamatsu, Japan.
Journal of palliative medicine
|December 29, 2025
概括
阿片类药物有效地减少了癌症患者所有预后的终端呼吸障碍. 然而,在即将死亡的患者中,不良事件增加,症状评估具有挑战性.
科学领域:
- 抚慰性护理是一种缓解性护理.
- 在瘤学瘤学.
- 临床药理学 临床药理学
背景情况:
- 终端呼吸障碍是晚期癌症的一个令人痛苦的症状.
- 了解阿片类药物的影响,不良事件和对这一群体的结果评估至关重要.
研究的目的:
- 在接受全身阿片类药物治疗的癌症患者中调查末端呼吸障碍的临床特征.
- 根据临床医生预测的生存期 (CPS) 将患者分类,并分析阿片类药物的影响.
主要方法:
- 在12个日本息治疗场所进行的前性观察研究的二次分析.
- 包括开始定期全身阿片类药物治疗呼吸障碍的成年癌症患者.
- 根据CPS,患者被分为"天" (1-14),"周" (15-56) 和"月" (>56天) 的类别. 呼吸障碍强度 (NRS,IPOS) 在72小时内进行评估. 评估不良事件和结果获取率.
主要成果:
- 招募了402名患者,186名 (日),174名 (周),42名 (月).
- 在所有预后组 (p < 0.001) 中观察到显著的呼吸障碍减轻 (NRS,IPOS).
- 在"天"组中,嗜睡和妄想增加;在这个组中,NRS评估下降了 (73.1%至55.2%),而IPOS评估仍然很高.
结论:
- 片类药物可以缓解与癌症相关的呼吸障碍,无论预后如何,但症状可能会持续.
- 即将死亡的患者在症状评估 (NRS) 中面临常见的不良事件和挑战.
- 需要进一步的研究来优化终端呼吸障碍的评估和管理策略.
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