前额叶皮层解剖学与自闭症谱系障碍之间的联系:一篇文学评论
Efthalia Tzila1, Eleni Panagouli2, Maria Tsouka3
1Department of Anatomy, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Acta medica academica
|December 29, 2025
概括
自闭症谱系障碍 (ASD) 与前额叶皮层 (PFC) 解剖学的变化有关,影响大脑功能,导致社会和情绪缺陷. 分子信号和微量元素在ASD病理生理学中发挥着关键作用.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 自闭症研究 自闭症研究
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,其特点是社会,情感和行为挑战.
- 前额叶皮质 (PFC) 对于执行功能,社会认知和情绪调节至关重要,这些领域在ASD中经常受到损害.
研究的目的:
- 审查和综合当前关于自闭症谱系障碍 (ASD) 前额叶皮层 (PFC) 结构和功能变化的文献.
- 调查分子信号通路和微量元素失衡在与ASD相关的PFC功能障碍中的作用.
主要方法:
- 进行了全面的文献审查.
- 搜索包括从2010年到2025年的学术出版物.
主要成果:
- 在ASD中,PFC的结构和功能异常明显,影响神经连接和突触可塑性.
- 神经化学平衡的破坏,包括来自大脑的神经营养因子 (BDNF) 失调和氧化应激,都与此有关.
- 微量元素的失衡与ASD中加剧的PFC功能障碍有关.
结论:
- 前额叶皮层 (PFC) 解剖学是自闭症谱系障碍 (ASD) 病理生理学的组成部分.
- PFC功能障碍对ASD中观察到的认知,社会和情绪缺陷有显著的贡献.
- 自闭症多因素的性质需要一个多维的研究方法来理解PFC的参与.
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