以色列的儿童肺移植:来自单一中心经验的29例病例
Eyal Jacobi1, Moshe Heching2, Osnat Shtraichman2
1Pulmonary Institute, Schneider Children's Medical Center, Petah Tikva, Israel, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
The Israel Medical Association journal : IMAJ
|December 29, 2025
概括
以色列的儿童肺移植显示出与国际数据一致的生存率,囊性纤维化是该程序的最常见原因. 慢性肺异位移植功能障碍是导致死亡的主要原因.
科学领域:
- 儿科肺病学 儿科肺病学
- 胸部外科手术 胸部外科手术
- 移植医学 移植医学
背景情况:
- 肺移植是末期肺病的关键干预措施.
- 儿童肺移植比成年人少.
- 常见的症状包括囊性纤维化,肺高血压和间歇性肺病.
研究的目的:
- 评估以色列最大的移植中心儿科肺移植的经验和结果.
主要方法:
- 自1997年以来进行的儿科肺部和心肺移植手术的回顾性审查.
- 收集的数据包括人口统计,适应症,临床参数,并发症和生存率.
- 分析的重点是患者的特征和移植后的结果.
主要成果:
- 进行了29例儿科肺/心肺移植手术 (3.0%的肺移植手术).
- 主要症状包括囊性纤维化 (44%),肺高血压 (17%) 和儿童间歇性肺病 (10%).
- 1,5,10年和15年生存率分别为90%,65%,55%和20%;慢性肺异位移植功能障碍是死亡的主要原因.
结论:
- 这项儿科肺移植计划的结果与国际注册数据一致.
- 具有多学科团队的集中计划可能会为有利的结果做出贡献.
- 存活率与移植指示或手术类型没有关联.
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