非结核菌感染与人造石结:一个案例系列
Shimon Izhakian1, Lena Slobodscoy Ignatov1, Alon Gorenshtein1
1Pulmonary Institute, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
The Israel Medical Association journal : IMAJ
|December 29, 2025
概括
非结核菌 (NTM) 感染可能发生在人造石症患者中,出现呼吸系统症状和特征性肺部变化. 早期诊断和微生物学评估对于管理这些具有挑战性的感染至关重要.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 职业健康 职业健康 职业健康
背景情况:
- 在慢性肺病中,非结核菌菌 (NTM) 感染的发病率不断上升.
- NTM感染带来了严重的发病率和死亡率挑战.
- 天然石中NTM是已知的,但在人造石中尚未探索.
研究的目的:
- 描述人工石症中NTM感染的临床,放射和病理特征.
- 在这个患者群体中强调早期诊断NTM的重要性.
主要方法:
- 对第三级医疗中心数据库 (2010-2024) 的回顾性审查.
- 识别有职业人工石症和NTM感染的患者.
主要成果:
- 发现了8名男性患者 (42-74岁) 患有人造石症和NTM感染.
- 症状包括呼吸不良,咳,体重减轻,发烧;CT显示淋巴腺病,纤维化,洞穴等.
- 活检发现了状结节,晶体,蛋白病,纤维化;4人死亡,6人需要肺移植.
结论:
- 人工石病可能与NTM感染有关.
- 高度的临床怀疑对于早期诊断至关重要.
- 病患者症状恶化需要进行微生物学评估 (菌培养,BAL).
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