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作为强大的抗结核剂,发现和优化氧衍生物的发现和优化,准FabD蛋白

Manyi Xu1, Lingling Xu1, Bin Wang1

  • 1Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.

Journal of medicinal chemistry
|December 29, 2025
PubMed
概括

研究人员发现了一种新的化合物,B10,来自质疑氨酸A,对抗耐药结核病表现出强大的活性. 这种新型药物向FabD酶,为开发新的多药耐药结核病疗法提供了一个有前途的战略.

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