在精神疾病中,孤独与海马对动态社会刺激的反应之间的关联
Faye McKenna1, Louis N Vinke1, Francesca de Marneffe1
1Department of Psychiatry and Athinoula A. Martinos Center, https://ror.org/002pd6e78Massachusetts General Hospital, Boston, MA, USA.
Psychological medicine
|December 29, 2025
概括
孤独与海马体和基底腺在观看退缩的面孔时增加大脑反应有关. 增加海马活动可能预测未来的孤独感,这表明干预的神经生物学标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 全球孤独率有所上升,特别是在患有严重精神疾病的人群中.
- 了解孤独的神经认知基础对于公共卫生干预至关重要.
研究的目的:
- 研究与孤独相关的神经认知机制.
- 检查与没有精神病障碍的个体对社会线索的大脑反应.
主要方法:
- 功能磁共振成像 (fMRI) 用于研究参与者观看接近与撤回的面部的大脑活动.
- 参与者评价了面部可信度,这被纳入了fMRI分析.
- 全脑回归分析与神经反应相关的孤独水平.
主要成果:
- 增加的孤独与更大的海马和基底质对心理障碍和完整样本中撤回面部的反应相关.
- 在控制社交活动,抑郁和社交无聊之后,海马体反应仍然很重要.
- 在一个子集中,对退出面孔的海马体更强的反应预测了一年后孤独感增加.
结论:
- 对退缩的面孔的海马体反应升高可能作为孤独的神经生物学标志物.
- 这一发现表明了旨在缓解孤独感的干预措施的潜在目标.
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