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Updated: Jul 28, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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双级联激活DNA酶纳米反应器在以Zn为基础的MOF中用于线粒体基因调节

Xiuyan Wan1, Yukun Tao1, Yingli Ge1

  • 1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China.

ACS applied materials & interfaces
|December 29, 2025
PubMed
概括

这项研究引入了一种用于肝细胞癌 (HCC) 基因治疗的新型纳米反应器. ZIF-90纳米反应器精确地准癌细胞线粒体,提供DNAzyme,以有效地静止基因和抑制瘤.

关键词:
这就是DNAzyme DNA酶.双层层次的连锁链.肝细胞癌是肝细胞癌.金属-有机的框架.线粒体基因疗法的基因疗法.

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相关概念视频

Ribozymes02:47

Ribozymes

The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
Ribozymes can be...