一项关于在丢弃的捐赠脏中BK和JC多聚马病毒的分布的研究
Wouter T Moest1,2, Aiko P J de Vries1,2, Reshma A Lalai1
1Division or Nephrology, Department of Internal Medicine, Leiden University Medical Center (LUMC), Leiden, Netherlands.
Frontiers in transplantation
|December 29, 2025
概括
在40%的已故捐赠脏中发现了JC多瘤病毒 (JCPyV) DNA,其在器官内分布不同. 没有检测到BK多种瘤病毒 (BKPyV),这表明JCPyV可能是移植前的捐赠者衍生.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 病毒学 病毒学
- 移植免疫学 移植免疫学
背景情况:
- BK多元瘤病毒 (BKPyV) 和JC多元瘤病毒 (JCPyV) 确立了持续的脏感染.
- 这些病毒的内储存和移植前存在尚不清楚.
研究的目的:
- 调查BKPyV和JCPyV在不同部位的局部化和潜在的移植前存在.
- 为了确定是否在移植前在捐赠脏中检测到JCPyV或BKPyVDNA.
主要方法:
- 来自10个已故捐赠脏的皮质,髓,骨和尿管样本的分析.
- 定量PCR (qPCR) 用于检测JCPyV和BKPyV的DNA.
主要成果:
- 在40%的脏中检测到JCPyVDNA (4/10).
- 在皮质,脑髓,骨盆和尿道中具有相似的JCPyV检测率.
- 在任何样本中都没有检测到BKPyV DNA.
- 在个体脏中,JCPyV分布和病毒载荷 (Ct值) 显著异质.
结论:
- 这些发现支持了移植前的假设,可能来自供体的JCPyV.
- JCPyV没有显示脏内明显的组织偏好.
- 需要进一步研究JCPyV在移植患者中的作用及其与BKPyV的关系.
相关概念视频
Kidney Transplant I: Introduction
304
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
304
Kidney Transplant II: Surgical Procedure
277
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
277
Blood and Nerve Supply to the Kidney
3.9K
The kidneys are vital organs responsible for filtering and cleaning blood, removing waste products, and regulating electrolyte levels. To perform these essential functions, they require a constant and robust blood supply.
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of...
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of...
3.9K
Acute Kidney Injury IV: Diagnostic Studies and Prevention
242
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
242
Kidney Transplant III: Nursing Management
287
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
287
Bone Marrow Sampling and Transplants
809
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
809


