语言网络的半球内和半球间连接性与在亚急性中风后失语症中语言改善之间的关系
Xiaohui Xie1, Yuqian Zhan2, Mengdan Zhang3
1Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Frontiers in neurology
|December 29, 2025
概括
在左半球语言网络中增加的半球内连接性可能预测中风后失语症 (PSA) 患者的语言恢复更好. 这种在残留网络中的增强连接性与中风后改善的语言功能有关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 认知科学 认知科学
背景情况:
- 语言处理依赖于复杂的大脑网络,平衡的连接对于功能至关重要.
- 脑卒中引起的损伤 (失语) 破坏了这个网络,但大脑的恢复机制尚未完全理解.
- 关键的问题仍然是恢复是否涉及左半球补偿,右半球上调,或两者兼而有之.
研究的目的:
- 与健康对照组 (HCs) 相比,研究中风后失语症 (PSA) 患者的语言网络中的功能连接 (FC) 差异.
- 探索PSA患者基线连接模式和随后的语言功能改善之间的关系.
- 为了确定恢复是否是由半球内或半球间连接变化驱动的.
主要方法:
- 休息状态功能磁共振成像 (rs-fMRI) 用于测量功能连接 (FC).
- 在一个定义的语言网络中,在32名PSA患者和70名HC患者中量化了FC.
- 在基线分析了连接模式,并与随时间的语言改进相关联.
主要成果:
- 与HC相比,PSA患者的内半球FC增加.
- 在PSA患者中,更高的基线半球内FC与语言功能改善正相关.
- 在PSA组中,半球内FC明显大于半球间FC.
结论:
- 改变语言网络连接是PSA语言缺陷的神经基础.
- 在左半球语言网络内增强的半球内连接性可能预测在亚急性PSA中更好地恢复语言.
- 基于网络的分析提供了关于损伤效应和中风后失言症的功能恢复机制的见解.
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