在急性缺血性中风患者的入院时系统性免疫炎症指数和中风后抑郁症之间存在关联
Xiaohang Su1, Fengtian Chi1, Jiulin You1
1Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Frontiers in neurology
|December 29, 2025
概括
在急性缺血性中风 (AIS) 患者中,系统性免疫炎症指数 (SII) 水平升高与患中风后抑郁症 (PSD) 的风险更高有关. 这种炎症标志物可能有助于早期识别PSD风险.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 脑卒中后抑郁症 (PSD) 是一种常见的并发症,影响中风幸存者的康复.
- 确定PSD的早期风险因素对于及时干预至关重要.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 在入院时与急性缺血性中风 (AIS) 患者的PSD发生之间的关联.
主要方法:
- 预计将招募318名AIS患者.
- 从入院时的血液样本计算SII (中性粒细胞数 × 血小板数/淋巴细胞数).
- 在中风后3个月使用汉密尔顿抑郁评分表 (HAMD-17) 评估抑郁症状.
主要成果:
- 30.82%的患者在3个月后出现PSD.
- 与非PSD患者相比,PSD患者的SII水平显著更高 (p < 0.001).
- 最高三分之一的SII与PSD风险增加3.5倍相关 (OR = 3.502,p = 0.002).
- 一个SII切断的602.503显示中等的PSD预测值 (AUC = 0.659).
结论:
- 入院时SII升高与AIS患者的PSD发展有关.
- SII可以作为一种有价值的炎症生物标志物,用于早期识别患PSD高风险的患者.
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