当预防变得病态时:一种LMWH诱导的亡病例与二次细胞炎
Mohammed AbuBaha1, Bara AbuBaha1, Hossam Salameh1
1Department of Medicine, An-Najah National University, Rafidia Street, Nablus P400, Palestine.
Oxford medical case reports
|December 29, 2025
概括
低分子量肝素 (LMWHs) 可能导致罕见的延迟过敏反应,导致皮肤亡. 早期识别和切换抗凝药对于管理这种严重并发症至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 低分子量肝素 (LMWHs) 是预防妊娠和产后血栓形成的标准.
- 虽然LMWH通常是安全的,但很少会引起延迟过敏反应.
- 这些反应可能表现为皮肤亡和感染,需要及时识别.
研究的目的:
- 为了突出一个罕见的LMWH诱导的皮肤亡病例.
- 强调早期诊断和治疗这种不良反应的重要性.
主要方法:
- 一个40岁妇女在剖腹产后分娩的案例介绍.
- 临床评估包括体检,炎症标志物和血小板计数.
- 诊断LMWH诱导的延迟过敏与二次细胞炎.
主要成果:
- 患者在埃诺沙巴林注射部位出现了痛苦的死角病变.
- 排除了氨酸诱导的血小板缺血.
- 通过停止服用埃诺沙巴林并开始替代性抗凝药 (阿皮克萨班),抗生素和伤口护理来实现恢复.
结论:
- 由LMWH引起的皮肤亡是一种罕见但严重的并发症.
- 反应通常在LMWH启动5-14天后出现,并模仿感染.
- 及时诊断和切换到替代抗凝剂对于积极的患者结果至关重要.
相关概念视频
Anticoagulant Drugs: Low-Molecular-Weight Heparins
1.6K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.6K
Venous Thrombosis III: Interprofessional Care
257
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
257
Peripheral Artery Disease V: Postoperative Nursing Management
347
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
347
Venous Thrombosis IV: Nursing Management
176
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
176
Venous Thrombosis I: Introduction
267
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
267
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
274
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
274


