关于牛皮中微RNA的研究趋势和见解:全面分析
Ismail Örs1, Nur Cihan Cosansu2, Berna Solak3
1Dermatology, Meram State Hospital, Konya, TUR.
Cureus
|December 29, 2025
概括
微RNAs (miRNAs) 是牛皮研究的关键,研究越来越多,并转向翻译应用. 这项分析绘制了研究格局,确定了生物标志物和临床用途的关键miRNA枢纽.
科学领域:
- 皮肤病学和生物信息学
- 专注于微RNA研究和牛皮的交集,利用信息学和翻译见解的文献计量和网络分析.
背景情况:
- 微RNAs (miRNAs) 在调节与牛皮相关的生物过程中起着至关重要的作用.
- 关于牛皮中miRNAs的全球研究格局缺乏系统的信息学和翻译映射.
- 了解这种景观对于推进牛皮的诊断和治疗至关重要.
研究的目的:
- 从信息学和翻译角度系统地绘制出银病中miRNAs的全球研究格局.
- 识别关键主题,有影响力的出版物,以及银病miRNA研究的新兴趋势.
- 突出潜在的miRNA生物标记物和牛皮的治疗点.
主要方法:
- 对来自Web of Science核心集合 (2003-2024) 的出版物进行了图书统计和网络分析.
- 在R中的VOSviewer和文献计量包被用于共同撰写,共同出现和引用网络构建.
- 我们使用了STRING数据库来总结蛋白质-蛋白质和miRNA-目标相互作用.
主要成果:
- 确定了449个出版物,年增长率为13.8%,引用量很高.
- 主题映射揭示了核心主题 (牛皮,炎症),运动主题 (miR-146a-5p,外体),以及新兴术语 (STAT3,Adalimumab).
- 确定了参与炎症和增殖途径的关键监管枢纽 (STAT3,PTEN,TRAF6),并将转化标签连接生物标志物和药物开发.
结论:
- 在牛皮中对miRNA的研究表明持续增长和向翻译应用的显著转变.
- 确定的miRNA中心和主题趋势为生物标志物小组选择和临床试验设计提供了基础.
- 这种证据地图可以为牛皮管理和治疗策略的临床决策支持提供信息.
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