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盆腔器官脱落的全球负担,1990-2021年:一个生态研究和孟德尔的随机化分析

Zhengkun Wang^1,2, Yi Rong^1,2, Qiwei Wang^1,2

¹The First hospital of Shanxi Medical University Shanxi China.

Health science reports

|December 29, 2025

概括

从1990年到2021年,盆腔器官脱落 (POP) 的负担在全球范围内增加,但年龄标准化率下降. 肥胖是一个危险因素,而教育可能是保护性的,预计到2036年,病例将增加.

科学领域:

流行病学流行病学
公共卫生公共卫生
遗传学遗传学是一个

背景情况:

骨盆器官脱落 (POP) 对女性来说是一个重大的全球健康挑战.
了解POP的疾病负担和风险因素对于有效的干预至关重要.

研究的目的:

从1990年到2021年,系统地分析POP的全球疾病负担和相关风险因素.
预测POP发病率和流行率的未来趋势.

主要方法:

利用了2021年全球疾病负担 (GBD) 数据库和全基因组关联研究 (GWAS).
用于趋势分析和预测的就业年龄时期队列 (APC) 和自动回归集成移动平均线 (ARIMA) 模型.
进行了双样本的门德尔随机化 (MR) 来调查与POP的遗传关联.

主要成果:

在1990年至2021年期间,全球POP的原始发病率,流行率和残疾调整后寿命年 (DALYs) 大幅增加.
从1990年到2021年,年龄标准化DALY率下降了18.4%,社会人口统计指数较低的地区负担更高.
肥胖和相关特征是可能的因果因素,而更高的教育水平显示出一种保护作用. 预计到2036年,全球病例将达到1.48亿.

结论:

人口老龄化和社会经济差异加剧了POP负担.
优先考虑全球监测,资源分配和针对高风险群体的有针对性的预防是至关重要的.

关键词:

门德尔的随机化流行病学流行病学全球疾病负担全球疾病负担健康不平等在健康不平等.骨盆器官脱落骨盆器官脱落

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