血小板表和凝血功能的应用,用于评估不同三个月的孕妇的凝血状况
Jiayu Li1, Jianfen Zhu2, Xiaoqian Chen2
1Clinical Laboratory, Zhangjiagang Second People's Hospital, Zhangjiagang, Jiangsu, China.
Frontiers in medicine
|December 29, 2025
概括
怀孕会导致血液凝固的显著变化,增加风险. 与标准测试相结合的血小板造影 (TEG) 在评估怀孕期间这些凝血变化时提供了更高的准确性.
科学领域:
- 产科和妇科 产科和妇科
- 血液学 血液学 血液学
- 麻醉学 麻醉学
背景情况:
- 怀孕自然会诱导高凝血状态,增加血栓形成和产后出血的风险.
- 在怀孕期间监测凝血对于孕产妇和胎儿的健康至关重要.
- 尽管对凝血进行了详细的评估,但血栓形成显微镜 (TEG) 仍未得到充分利用.
研究的目的:
- 用标准测试和TEG.来调查整个怀孕期间的凝血变化.
- 评估结合TEG与传统凝血试验的诊断准确性.
主要方法:
- 对92名孕妇 (按三个月) 和30名非孕妇对照进行了回顾性研究.
- 测量了标准凝血指标 (PT,APTT,TT,纤维素) 和TEG参数 (R,K,α角,MA).
- 比较三个月的结果和对照结果;执行ROC分析.
主要成果:
- 与对照组相比,怀孕显示PT,APTT,TT下降,纤维素素增加 (p<0.05).
- TEG显示R和K下降,α角和MA在三个月内增加 (p<0.05).
- 结合TEG和传统测试,AUC达到0.876,敏感度为84.0%,特异性为83.6%.
结论:
- 凝血参数在怀孕期间发生显著变化,表明高凝血状态.
- 将TEG与标准测试相结合,可以提高对凝血异常的早期检测,从而改善围产期结果.
- 结果描述了生理适应;在健康怀孕中不支持常规TEG查.
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