在接受血管内移植植入的患者中,基于微生物群的感染风险生物标志物:试点研究
Arianna Delicati1,2,3, Elda Chiara Colacchio4, Beatrice Marcante1,2,3
1Legal Medicine Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Frontiers in medicine
|December 29, 2025
概括
皮肤和口腔微生物组中的微生物失衡可能预测血管内移植手术后的医疗相关感染 (HAI). 确定了特定的细菌模式,可以帮助进行手术患者的手术前风险评估.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 医疗器械 医疗器械
背景情况:
- 医疗相关感染 (HAI) 是一个重要的全球健康问题,增加了患者的发病率,死亡率和医疗保健支出.
- 手术后和与设备相关的HAI具有严重的临床风险.
- 主体,植入器件和人类微生物群之间的相互作用是HAI开发的兴趣新兴领域.
研究的目的:
- 研究皮肤和口腔微生物群在进行血管内移植 (VEG) 植入的患者中的预测性和病原性作用.
- 为了比较患有HAI和未患有HAI的患者之间的微生物概况,识别潜在的风险生物标志物和异位生物模式.
主要方法:
- 利用16S rRNA基因测序来分析皮肤和口腔微生物群落.
- 对那些患有HAI (HAI组) 和没有 (NoHAI组) 患者的微生物特征进行了比较.
主要成果:
- 口腔微生物群的多样性在HAI组减少,而皮肤微生物群的多样性与NoHAI组相比显著更高.
- 特定的细菌种群,包括Firmicutes,Staphylococcus,Haemophilus,Prevotella denticola和Streptococcus mutans,与增加的HAI易感性有关.
结论:
- 初步发现表明,皮肤和口腔样本中的显著微生物特征可能使患者在VEG植入后易患HAI.
- 这些微生物签名为手术前风险分层和手术环境中的个性化预防策略提供了潜在的潜力.
- 需要在更大,更多样化的手术群体中进一步验证.
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