使用贝叶斯优化的支持向量机器预测冠状动脉疾病,具有特征选择
Abdul Zahir Baratpur1, Hamed Vahdat-Nejad1, Emrah Arslan2
1Faculty of Electrical and Computer Engineering, University of Birjand, Birjand, Iran.
Frontiers in network physiology
|December 29, 2025
概括
本研究引入了一种使用机器学习预测冠状动脉疾病 (CAD) 的非侵入性框架,实现了高准确性并为临床使用提供可解释的结果.
科学领域:
- 心血管研究的心血管研究.
- 医疗信息学医学信息学
- 机器学习在医疗保健中的应用
背景情况:
- 冠状动脉疾病 (CAD) 是一个主要的全球健康问题.
- 目前的诊断方法,如侵入性血管造影,是昂贵的,并带有风险.
- 需要非侵入性,准确和可解释的CAD预测工具.
研究的目的:
- 开发和验证用于冠状动脉疾病 (CAD) 预测的非侵入性,可解释的框架.
- 利用机器学习来提高CAD风险分层.
- 确定用于CAD预测的临床相关特征.
主要方法:
- 使用Z-Alizadeh Sani数据集进行模型开发.
- 采用混合决策树-AdaBoost来进行功能选择 (30个功能).
- 在交叉验证折叠中应用SMOTE过量抽样,以防止数据泄露.
- 优化支持向量机 (SVM) 使用贝叶斯式超参数调.
- 使用夏普利添加式扩展 (SHAP) 解释模型预测.
主要成果:
- SVM_贝叶斯模型实现了97.67%的准确性,100%的灵敏度和99%的AUC.
- 性能优于后勤回归,随机森林,标准SVM和SLOA优化的SVM.
- SHAP分析确定了典型的胸痛和年龄等关键预测因素.
- 统计测试和时间概括证实了模型的稳定性.
结论:
- 拟议的框架为CAD风险分层提供了一个透明,可泛化和临床可行的工具.
- 证明了可解释机器学习在心血管疾病预测中的潜力.
- 强调了心血管特征相互联系在系统性疾病预测中的重要性.
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