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工程优化纳米结构脂质载体的阿斯塔山丁:一个响应表面方法方法方法

Nur Rafiqah Abdol Wahab¹, Meor Mohd Redzuan Meor Mohd Affandi², Sharida Fakurazi¹

¹Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Serdang, SEL, Malaysia.

International journal of nanomedicine

|December 29, 2025

概括

这项研究开发了优化纳米结构脂质载体 (NLC) 进行阿斯塔山丁的输送. 这种新型配方显著提高了阿斯塔山丁封装效率,为提高口服生物利用率铺平了道路.

科学领域:

药理学药理学是指药理学的学科.
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

作为一种强有力的抗氧化剂的阿斯丁,具有较差的溶解性和生物可用性.
纳米结构脂质载体 (NLC) 为口服输送疏水化合物提供了一个有前途的解决方案.
无毒链提供了卓越的生物相容性,稳定性和药物载荷能力.

研究的目的:

开发和优化使用可可黄和棕油的阿斯塔丁载荷NLC.
用响应表面方法 (RSM) 来优化纳米配方.
为了表征阿斯塔丁载荷的NLC的物理化学特性.

主要方法:

使用了响应表面方法 (RSM) 与中央复合设计 (CCD).
分析了独立变量 (可可黄,棕油,Tween 80) 对它们对NLC特性的影响.
测量了粒子大小,多分散度指数 (PDI),泽塔潜力和封装效率.

主要成果:

配方成分显著影响了NLC粒子大小,PDI和zeta潜力.
优化的NLCs的粒子大小为254.42 ± 3.91 nm,PDI为0.38 ± 0.01,而zeta电位为-30.54 ± 0.85 mV.
获得了99.69±0.0003%的非凡的阿斯塔克桑封装效率.

结论:

优化的NLC配方表现出理想的物理化学特性,用于口服阿斯塔山丁的输送.
RSM有效地预测和优化了NLC特征.
这种纳米结构系统有可能增强阿斯塔克桑的临床应用.

关键词:

这是一种阿斯塔克桑.中心复合设计设计的中心复合设计.药物输送是药物输送的过程.纳米制剂的纳米配方纳米结构脂质载体纳米结构脂质载体响应表面方法的方法.

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