在儿科患者中评估胃肠道对比剂的安全性:一项回顾性研究
Abdullah Alshehri1, Rayan Hejles2, Mohammad Aldaffaa3
1Pediatric Surgery, King Saud University, Riyadh, SAU.
Cureus
|December 29, 2025
概括
胃肠道对比成像对婴儿来说是安全的,并且不会增加死性肠球炎 (NEC) 的风险. 在活跃的NEC病例中,应避免使用超体剂.
科学领域:
- 儿科放射学 儿科放射学
- 新生儿胃肠病学 新生儿胃肠病学
- 临床安全研究临床安全研究
背景情况:
- 胃肠道 (GI) 对比成像是儿科患者的常见诊断工具.
- 对于对比剂对婴儿肠壁的潜在不良影响存在担忧,特别是在早产或有炎症的婴儿中.
- 这些担忧在很大程度上是基于事证据和较旧的动物研究.
研究的目的:
- 评估胃肠道对比剂暴露与婴儿30天内死亡性肠球炎 (NEC) 发病率之间的关联.
- 为了解决关于GI对比剂在脆弱婴儿群体中的安全性的临床不确定性.
主要方法:
- 在一个单一的第三级护理机构进行了回顾性研究,该机构设有IV级NICU.
- 包括245名婴儿接受了GI对比增强放射学研究.
- 主要结局:对比剂暴露后30天内NEC的发展.
主要成果:
- 在245名婴儿中,15名 (6.1%) 在成像检查前两周内有过NEC诊断.
- 一个怀疑NEC的新生儿在对比剂暴露后经历了肠道穿孔.
- 在使用对比剂后的30天内,没有观察到NEC发病率的增加.
结论:
- 暴露于GI对比剂似乎对婴儿,包括早产新生儿来说是安全的,在30天内不会增加NEC风险.
- 建议小心谨慎,建议在患有活性NEC的婴儿中避免使用高度对比剂.
- 进一步的研究可能会完善新生儿肠道成像中对比剂使用的安全协议.
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