前列腺成像报告和数据系统 (PI-RADS) 评分和前列腺特异性抗原密度 (PSAD) 与前列腺活检组织学结果的关联:一项回顾性研究
Vignesh Balasubaramaniam1, Anurag Agarwal2, Ashok Kailasa3
1Surgery, Betsi Cadwaladr University Health Board, Bangor, GBR.
Cureus
|December 29, 2025
概括
高前列腺特异性抗原密度 (PSAD) 和前列腺成像报告和数据系统 (PI-RADS) 评分强烈预测侵袭性前列腺癌 (格里森≥7). 此外,PSAD还改善了PI-RADS 3病变的风险分层,有助于做出活检决策.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 前列腺癌的诊断依赖于成像和生物标志物.
- 精确预测活检组织学对于患者管理至关重要.
研究的目的:
- 评估前列腺成像报告和数据系统 (PI-RADS) 和前列腺特异性抗原密度 (PSAD) 与前列腺活检结果的关联.
- 为了确定PSAD是否增强PI-RADS 3病变的风险分层.
主要方法:
- 追溯分析594个跨关节前列腺活检.
- 数据包括年龄,PSA,前列腺体积,PI-RADS得分和格里森等级.
- 多项逻辑回归评估PI-RADS,PSAD和活检结果之间的关联 (良性,格里森6,格里森≥7).
主要成果:
- 高PSAD (≥0.15 ng/mL2) 和高PI-RADS (4-5) 独立地与格里森≥7种癌症相关 (分别为OR 5.63和9.14,p<0.001).
- 年龄预测了临床显著的癌症,但不是格里森1病.
- PI-RADS 3显示的趋势不显著,但PSAD增加了歧视性价值.
结论:
- 提升的PSAD和高PI-RADS得分是格里森≥7前列腺癌的强有力的预测因素.
- PSAD是改进PI-RADS 3病变风险评估的宝贵工具,可能改进活检策略.
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