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Updated: Jan 7, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
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Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

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调节·维勒布兰德因子A1/A2相互作用的关键残留物:从分子动力学模拟和实验验证实验中的见解

Jinhua Fang1, Zhiwei Wu1,2, Junxian Yang3

  • 1Department of Medical Research, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

Research and practice in thrombosis and haemostasis
|December 29, 2025
PubMed
概括

研究人员确定了关键残留物 (D1323,R1334,A1上的Q1367和V1546,A2上的R1575,E1598) 对·维勒布兰德因子A1/A2相互作用至关重要. 这一发现为治疗出血障碍提供了新的目标.

关键词:
一个A1/A2的相互作用.航空飞行管理 (AFM)一个 BLI 一个 BLI.在VWF中使用VWF.分子动力学模拟模拟

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