心力衰竭死亡率的性别差异按射出分数亚型:一个单中心,回顾性队列研究
Abiden Kapar1,2,3, Xingli Gu4, Fengwei Liang2,3
1School of Biomedical Engineering, Hainan University, Sanya, China.
Frontiers in cardiovascular medicine
|December 29, 2025
概括
年龄是心力衰竭 (HF) 死亡率的关键风险因素. 女性性别独立地预测轻微减少喷射分数 (HFmrEF) 的死亡率,强调需要性别特定的HF管理.
科学领域:
- 心脏病学 心脏病学
- 临床医学 临床医学
- 公共卫生 公共卫生
背景情况:
- 心力衰竭 (HF) 是全球疾病和死亡的主要原因.
- 了解高频结局的性别特异性对于有效治疗至关重要.
- HF包含了包括HFrEF,HFmrEF和HFpEF在内的子类型,每个都有不同的特征.
研究的目的:
- 为了研究跨高频率亚型的性别特异性死亡率差异.
- 确定HF患者全因死亡率的独立预测因素.
- 根据性别量身定制的风险分层和心力衰竭的管理策略提供信息.
主要方法:
- 对来自中国单一中心的6091名HF患者进行了回顾性队列研究.
- 使用了考克斯的比例危险回归和卡普兰-梅尔分析.
- 数据包括人口统计,临床参数和HF亚型 (HFrEF,HFmrEF,HFpEF).
主要成果:
- 年龄是HF患者全因死亡率的独立预测因素 (aHR:1.04).
- 女性性别是死亡率的独立预测因素,特别是在HFmrEF亚组 (aHR:4.75).
- 没有观察到有意义的基于性别的总体死亡率差异 (p=0.12).
结论:
- 年龄是HF死亡率的重要独立风险因素.
- 女性性别是HFmrEF死亡率的关键预测因素,需要量身定制的方法.
- 性别特定的风险分层和管理对于优化心力衰竭结果至关重要.
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