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益生菌对母体肠道和牛奶微生物群的调节以及对婴儿在产前期微生物发育的潜在影响
Kian Deng Tye1, XiaoYi Liu2, Chan Huang1
1Department of Obstetrics, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Frontiers in cellular and infection microbiology
|December 29, 2025
概括
怀孕期间补充益生菌可能会改变母亲的肠道和牛奶微生物,可能会影响婴儿的免疫发育. 这项研究探讨了这些复杂的饮食-微生物群-免疫相互作用对孕产妇和新生儿的健康弹性.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 益生菌,即活微生物,正在探索肠道微生物群的调节.
- 它们在怀孕和婴儿期的使用缺乏确的证据.
- 这项研究调查了益生菌对母亲/婴儿微生物群和营养摄入量的影响.
研究的目的:
- 评估益生菌补充剂对母体肠道和牛奶微生物群的影响.
- 检查孕期益生菌摄入量与营养消耗之间的关系.
- 探索早期生命中潜在的免疫编程影响.
主要方法:
- 23名孕妇被分为益生菌和对照组.
- 使用16S rRNA基因测序分析的便和牛奶微生物群.
- LEfSe,WGCNA和预测建模确定了微生物和饮食的关联.
主要成果:
- 营养摄入量或整体微生物多样性没有显著差异.
- 在母体肠道和牛奶中发现的不同微生物属与益生菌使用有关.
- 与益生菌相关的微生物群体显示出强大的分类,表明功能转变.
结论:
- 益生菌补充剂可以调节母体肠道和牛奶微生物群.
- 这些变化可能会影响母婴二合体中的微生物识别和免疫信号.
- 研究结果提供了通过微生物群调节增强母亲和新生儿健康弹性方面的见解.
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