通过EWMA支持的统计机制 (e-PSQC) 分析聚合血清作为免疫试验参数内部质量控制的实用性:与商业上可用的材料和Westgard规则进行比较
Prakruti Dash1, Saurav Nayak1, Tanushree Roy1
1Department of Biochemistry, All India Institute of Medical Sciences, Bhubaneswar, India.
EJIFCC
|December 29, 2025
概括
聚合血清为免疫测试提供了具有成本效益的内部质量控制 (IQC). 当与指数加权移动平均 (EWMA) 分析相结合时,聚合血清显示出稳定的性能,并增强临床实验室的早期错误检测.
科学领域:
- 临床生物化学 临床生物化学
- 实验室医学 实验室医学
- 质量控制 质量控制 质量控制
背景情况:
- 内部质量控制 (IQC) 对于临床实验室的可靠诊断测试至关重要.
- 商业IQC材料很昂贵,而且供应有限.
- 来自患者样本的聚合血清 (PS) 提供了一个具有成本效益的IQC替代方案,但需要验证.
研究的目的:
- 使用EWMA评估聚合血清作为免疫试验的IQC材料.
- 将聚合血清IQC性能与商业IQC材料进行比较.
主要方法:
- 从被丢弃的患者样本中准备和储存了聚合血清.
- 使用聚合血清和商业IQC,在60天内监测了5个免疫测试参数.
- 用7天光滑窗口的EWMA图表用于错误检测分析.
主要成果:
- 聚合血清IQC (ePSIQC) 的表现与商业IQC非常接近.
- 对于大多数参数,EWMA的分析显示了显著的一致性.
- 与传统方法相比,ePSIQC表现出优越的早期错误检测.
结论:
- 与EWMA合并的血清为免疫试验提供了稳定,成本效益和可靠的IQC.
- EWMA 增强了错误检测,改善了实验室的质量控制.
- 这种方法对于资源有限的环境来说是一个可行的解决方案.
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