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Updated: Jan 7, 2026

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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与阿尔茨海默病风险相关的PLCG2表达和拼接的遗传学

Andrew K Turner1, Kennedy Dotson1, Qi Qiao2

  • 1Department of Physiology and Sanders-Brown Center On Aging, University of Kentucky, 789 S Limestone St., Lexington, KY 40536 USA.

Molecular neurodegeneration advances
|December 29, 2025
PubMed
概括

靠近PLCG2的基因变异通过改变PLCG2表达和拼接来影响阿尔茨海默病 (AD) 风险. 具体来说,rs1071644通过促进非功能性PLCG2异型,D65-PLCG2.2,增加AD风险.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.遗传学 是一个遗传学.这就是PLCG2的原因.通过RNA拼接进行RNA拼接.

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