治疗中的益生菌:对疗效和安全性的元分析
Kang Tan1,2, Yunfeng Yu1, Pei Liu1
1School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.
Frontiers in microbiology
|December 29, 2025
概括
益生菌显著改善了控制,并减少了患者的发作频率和持续时间. 这项研究表明,益生菌是一种安全的补充治疗神经系统疾病,增强肠道屏障功能.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 益生菌对治疗神经疾病的益生菌越来越感兴趣.
- 是一种慢性神经系统疾病,影响着全世界数以百万计的人.
- 肠-大脑轴在神经健康中起着至关重要的作用.
研究的目的:
- 评估益生菌补充剂在管理中的有效性和安全性.
- 评估益生菌对活动,EEG模式和肠道屏障标记物的影响.
- 综合随机对照试验 (RCT) 关于在中使用益生菌的证据.
主要方法:
- 在2025年5月31日之前,对八个RCT数据库进行系统的文献搜索.
- 包括/排除标准选,数据提取和偏差风险评估.
- 使用RevMan 5.3进行元分析,敏感性分析和出版偏差评估;证据质量由GRADEpro GDT评分.
主要成果:
- 与656名患者进行的6项RCT显示,益生菌显著增加了临床疗效率,并减少了发作的频率和持续时间.
- 益生菌导致EEG θ带相对功率,血清二胺氧化酶 (DAO) 和D-乳酸盐 (D-LAC) 水平显著降低.
- 在益生菌和对照组之间没有观察到不良反应率或其他EEG频段 (δ,α,β) 的显著差异.
结论:
- 益生菌显示出作为的补充疗法的潜力,可以改善控制和肠道屏障功能,而不会增加不良影响.
- 这些发现支持肠-大脑轴在管理中的作用.
- 由于样本规模有限和方法考虑,需要进一步验证.
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