确定正常舌状细胞的参考值:对非典型变化的调查
Eiji Mitate1, Takeru Oyama2, Yasuhisa Sawai1
1Department of Oral & Maxillofacial Surgery, Faculty of Medicine, Kanazawa Medical University, Ishikawa, Japan.
CytoJournal
|December 29, 2025
概括
本研究以核与细胞质比率 (NCRs) 和核亮度为基础,为舌头粘膜细胞建立了客观的参考值. 这些定量测量有助于通过确定正常细胞特征来早期检测口腔癌.
科学领域:
- 细胞病理学 细胞病理学
- 口腔病理学 口腔病理学
- 定量细胞学 定量细胞学
背景情况:
- 非典型细胞的细胞学评估依赖于与正常细胞的主观比较.
- 一个普遍接受的定义的定义.
- 正常细胞的正常细胞.
- 缺少,导致诊断的变化.
- 需要客观的标准来准确评估舌头粘膜细胞.
研究的目的:
- 建立用于舌头粘膜细胞学评估的定量参考值.
- 定义核对细胞质比 (NCR) 和核亮度的正常范围.
- 为早期检测口腔癌提供客观标准.
主要方法:
- 从7名舌头粘膜病变患者收集了细胞学样本.
- 使用Papanicolaou (Pap) 染色用于样品制备.
- 使用ImageJ软件分析图像以量化NCR和亮度值 (BV).
- 使用钢-杜瓦斯测试进行统计分析.
主要成果:
- 在Pap类1,3和5之间发现了NCR和核BV的显著差异.
- 对正常细胞的定义参考值:平均NCR为0.031 ± 0.015 (第1类),0.074 ± 0.048 (第3类) 和0.307 ± 0.170 (第5类).
- 核BV范围随着帕普类增加而扩大.
结论:
- 核与细胞质比 (NCR) 和核亮度是语言粘膜细胞评估的客观标准.
- 这些定量发现为早期检测口腔恶性疾病提供了标准.
- 为更标准化的细胞病理学分析奠定了基础.
相关概念视频
01:26Assessment of the Mouth
962
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
962
00:49The Tongue and Taste Buds
40.4K
The surface of the tongue is covered with various small bumps called papillae, which either distribute what has been ingested (filiform papillae) or contain the sensory taste (or gustatory) receptor cells (fungiform, circumvallate, and foliate papillae). Embedded within each taste-related papilla are the taste buds—clusters of 30 to 100 gustatory receptor cells.
40.4K