美国成年人的胆结石和关节炎之间的关联:一个横截面的NHANES研究
1Department of Gastroenterology, Hui Ya Hospital of The First Affiliated Hospital, Sun Yat-sen University, Huizhou, China.
Preventive medicine reports
|December 29, 2025
概括
胆结石与关节炎有关,特别是美国成年人的骨关节炎. 这种关联在患有骨关节炎的女性中更为强烈.
科学领域:
- 流行病学 流行病学
- 类风湿病学 类风湿病学
- 胃肠病学 胃肠病学
背景情况:
- 胆结石和关节炎是常见的疾病.
- 胆结石和关节炎之间的关系需要进一步研究.
研究的目的:
- 检查美国成年人的胆结石和关节炎 (骨关节炎,类风湿性关节炎) 之间的关联.
- 探索人口统计和临床因素对潜在效果的改变.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2017-2023) 的横截面分析.
- 使用了加权的多变量逻辑回归模型.
- 进行了子组和相互作用分析.
主要成果:
- 胆结石与关节炎 (OR: 1.49) 和骨关节炎 (OR: 1.55) 有着显著的关联.
- 在胆结石和类风湿性关节炎之间没有发现显著的关联.
- 在女性中观察到胆结石和骨关节炎之间更强的关联 (OR:1.81),性别显著影响修改 (P=0.02).
结论:
- 胆结石与骨关节炎有显著的关联,特别是在女性中.
- 这些发现表明,胆结石和骨关节炎之间存在潜在的联系,这需要进一步研究因果关系.
相关概念视频
Genome-wide Association Studies-GWAS
15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.2K
Diseases of the Liver and Gallbladder
1.8K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.8K
Gallbladder
1.9K
The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
1.9K
Chronic Pancreatitis I: Introduction
644
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
644
Gastritis-II: Pathophysiology
1.1K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.1K
Chronic Pancreatitis II: Collaborative Care
284
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
284


