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Updated: Jan 7, 2026

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评估T细胞概况通过古塞尔库马布对牛皮的IL-23抑制而发生的转变

Yoshifumi Kanayama1, Oki Watanabe1, Mai Sakurai1

  • 1Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

JID innovations : skin science from molecules to population health
|December 29, 2025
PubMed
概括

与古塞尔库马布 (guselkumab) 一样,抗干联素-23 (IL-23) 抗体疗法会改变牛皮的免疫细胞概况. 基线免疫细胞基因表达可以预测患者对这种IL-23p19抑制剂的反应.

关键词:
它们有IL-23和IL-23.牛皮是一种病.监管性T细胞 监管性T细胞定居记忆T细胞 定居记忆T细胞

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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