胃癌中的瘤相关巨细胞在免疫逃避中的双重作用和针对性治疗的临床影响
Chang Wang1, Xu Fan2, Xiaomen Sun1
1College of Continuing Education, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Frontiers in immunology
|December 29, 2025
概括
与瘤相关的巨细胞 (TAMs) 驱动胃癌 (GC) 的进展和免疫逃避. 针对TAMs,特别是M2表型,提供了一种有前途的策略,以增强免疫疗法并改善GC患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 胃癌 (GC) 是一个重大的全球健康挑战,死亡率高.
- 瘤相关巨细胞 (TAMs) 是瘤微环境 (TME) 中的关键参与者,影响GC进展.
- TAMs通常采用一种免疫抑制的M2类表型,促进瘤生长和转移.
研究的目的:
- 审查TAM在胃癌进展中的多方面的作用.
- 评估针对GC中TAM的新兴治疗策略.
- 探索TAM向疗法如何改善免疫疗法的疗效和患者的治疗结果.
主要方法:
- 在GC中对TAM研究的文献综述.
- 分析TAM功能,包括免疫抑制,血管新生和转移.
- 对TAM向疗法的临床前数据的评估.
主要成果:
- 通过检查点表达和细胞因子信号传递,TAMs有助于免疫逃避.
- 通过TAMs进行外体介导的交叉声会促进化学抵抗和入侵.
- TAM密度和表型与GC预后和治疗反应相关.
结论:
- TAMs是GC进展和治疗耐药性的关键调节者.
- 通过耗尽,重编程或信号封锁来准TAM显示出治疗潜力.
- 像MENK,帕克利塔塞尔和NF-κB抑制剂这样的干预措施需要对GC治疗进行进一步的研究.
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