内鼻喷雾器件和配方的机械导向参数建模,用于向向鼻和鼻的药物输送
Md Tariqul Hossain1, Abir Malakar1, Mohammad Yeasin1
1Department of Mechanical Engineering, South Dakota State University, Brookings, SD, United States.
Frontiers in drug delivery
|December 29, 2025
概括
优化鼻喷液滴滴大小和圆角可以提高药物输送到鼻,提高呼吸道感染的疗效. 这项研究确定了针对性鼻内药物沉积的关键参数.
科学领域:
- 生物医学工程 生物医学工程
- 制药科学 制药科学
- 计算流体动力学的流体动力学.
背景情况:
- 提高鼻喷剂的疗效需要优化药物输送到特定的气道部位.
- 鼻是鼻内药物输送的关键目标,因为它在病毒早期进入中的作用.
研究的目的:
- 调查鼻喷雾装置和配方参数对鼻喉中药物沉积的影响.
- 确定最佳参数,以增强针对性的鼻内药物输送.
主要方法:
- 利用大模拟 (LES) 与拉格朗日粒子跟踪相结合,模拟空气流和粒子沉积.
- 模拟的惰性颗粒 (10-50μm) 在两个解剖上呼吸道几何结构中,每分钟15升的空气流量.
- 不同的颗粒大小,配方密度 (1.0-1.5 g/mL) 和喷雾角 (15°-70°).
主要成果:
- 鼻沉积的峰值发生在颗粒大小为25-45微米和角≤30°的颗粒中.
- 平均鼻沉积率在这些最佳参数范围内达到约11.4%.
- 配方密度为1.0g/mL,导致最高的平均沉积率.
结论:
- 合理优化鼻内喷雾剂的向鼻沉积是可以实现的.
- 在喷滴子大小和装置羽毛角的可操作的设计修改可以显著提高药物输送效率.
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