抑郁症中自传记忆失调背后的神经系统:神经成像元分析
Cheuk Chi Charlotte Cheng1, Michelle Hei Lam Tsang1, Mengfan Han2
1Department of Psychology, MIND & AI Lab, The University of Hong Kong, Hong Kong SAR, China.
Psychological medicine
|December 29, 2025
概括
抑郁症中的自传记忆 (AM) 功能障碍涉及背前环膜 (dACC) 和前环膜 (precuneus) 中的大脑活动的改变,而不是杏仁体或海马体. 这些变化会影响抑郁症中的情绪和认知过程.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 精神病学是一个精神病学.
背景情况:
- 自传记忆 (AM) 功能障碍与抑郁症有关,但神经成像研究显示结果不一致.
- 现有的模型往往侧重于杏仁体和海马体的功能,这需要进一步调查.
研究的目的:
- 通过神经成像元分析,识别抑郁症中AM功能障碍的强有力的神经标记物.
- 描述与抑郁症中AM功能障碍相关的行为和网络水平机制.
- 调查单极抑郁症和风险人群中AM回忆的神经相关物.
主要方法:
- 功能磁共振成像 (fMRI) 研究的预注册的神经成像元分析.
- 包括341名单极性抑郁症患者,82名风险人群和261名健康对照者的数据.
- 进行了超分析网络层面和行为解码分析.
主要成果:
- 抑郁症组在AM回忆过程中显示出右侧带皮层 (dorsal anterior cingulate [dACC]) 和前皮层的激活增加,以及AM回忆期间前岛的激活减少.
- 消极的AM回忆与增加的DACC和前性活动有关.
- dACC与突出网络,负面影响和执行控制相关;与默认模式网络,社会认知和AM相关.
结论:
- 这些发现挑战了涉及杏仁体和海马体在与抑郁症相关的AM缺陷中的模型.
- 突出突出和默认模式网络,特别是dACC和precuneus在AM功能障碍中的作用.
- 这些网络变化可能是抑郁症中情感,社会认知和记忆障碍的基础.
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