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通过基于结构的虚拟选和碎片融合,发现1-甲基) -2--罗利丁衍生物作为新型POLθ-pol抑制剂

Wenlin Fan1, Mengyuan Qiu2, Zhenwei Wang1,3,4

  • 1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Drug development research
|December 29, 2025
PubMed
概括

研究人员发现了一种新化合物F-1,它有力抑制DNA聚合酶甲基 (POLθ). 这种POLθ抑制剂通过减少癌细胞增殖,显示出治疗BRCA缺陷瘤的前途.

关键词:
波利特抑制剂 (POLθ 抑制剂) 是一种碎片 融合 碎片 融合 碎片分子动力学模拟模拟虚拟选 虚拟选 虚拟选

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