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甘巴拉的作用缓解多克索鲁比诱导的肝损伤

Fazile Nur Ekinci Akdemir¹, Mustafa Can Güler², Ersen Eraslan³

¹Department of Physiology, Erzurum Medicine Faculty, Health Sciences University, Erzurum, Turkey.

Journal of biochemical and molecular toxicology

|December 29, 2025

概括

甘拉丁 (GAL) 通过减少氧化应激和炎症,防止多克索鲁比 (Dox) 诱导的肝脏和脏损伤. 这项研究突出了GAL GAL的特点.

科学领域:

药理学和毒理学药理学和毒理学
生物化学生物化学
病理学病理学病理学

背景情况:

多克索鲁比 (Dox) 是一种强大的化疗剂,具有显著的肝毒性.
氧化应激和炎症是Dox引起的器官损伤的关键机制.
识别保护剂对于减轻Dox的副作用至关重要.

研究的目的:

在大鼠模型中研究加拉 (GAL) 对Dox诱导的肝中毒性的保护作用.
评估GAL对氧化应激,炎症和特定分子标记物的影响 (IL-6,8-OHdG,AQP-1).

主要方法:

雄性斯普拉格-道利大鼠被给予多克斯和不同剂量的ALG (50和100毫克/公斤).
进行生物化学分析以评估抗氧化酶水平 (GSH,SOD,CAT) 和脂质过氧化 (MDA).
进行了组织病理学检查和炎症标志物 (IL-6) 和DNA损伤 (8-OHdG) 的测量.

主要成果:

GAL显著降低了Dox诱导的肝损伤,改善了他的病理概况.
治疗GAL降低了中白素-6 (IL-6) 和8-氧化氨酸 (8-OHdG) 的水平,这表明炎症和DNA损伤减少.
通过增加谷氨 (GSH),超氧化物失调酶 (SOD) 和催化酶 (CAT),同时降低甲酸 (MDA),GAL表现出抗氧化特性.

结论:

甘拉丁对多克索鲁比诱导的肝毒性有显著的保护作用.
通过减轻氧化应激和炎症,GAL可以减轻毒性.
甘巴林是一种潜在的治疗药物,用于控制Dox诱导的器官损伤和相关的炎症状况.

关键词:

德克索鲁比辛 (doxorubicin) 是一种药物.盖拉宁 (Galangin) 是一个有趣的小镇.肝脏和鼻腔损伤的损伤这是一种炎症炎症炎症炎症.氧化应激是一种氧化应激.

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