相关实验视频

Updated: Jan 7, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

8.7K

由CTCF协调的3D增强器架构通过RNA聚合酶II在CD4+T细胞中的暂停释放来确定与免疫相关的基因表达模式

Eun-Chong Lee1, Kyungwoo Kim1,2, Sugyung Kim1,2

  • 1Department of Tropical Medicine, Institute of Tropical Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.

Nucleic acids research
|December 29, 2025
PubMed
概括

CCCTC结合因子 (CTCF) 枯竭重组T细胞中的3D基因组架构. 然而,活性转录维持增强器循环,影响基因表达和JAK抑制剂反应,独立于CTCF.

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Identification of Enhancer-Promoter Contacts in Embryoid Bodies by Quantitative Chromosome Conformation Capture 4C10:02

Identification of Enhancer-Promoter Contacts in Embryoid Bodies by Quantitative Chromosome Conformation Capture 4C

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