侵袭性测量大动脉脉压和侵袭性冠状动脉血管学患者的长期预后:一项前性观察性研究
Hack-Lyoung Kim1, Soonil Kwon, Hyun Sung Joh
1Division of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
Journal of hypertension
|December 29, 2025
概括
在冠状动脉造影期间测量的侵入性大动脉脉压 (aPP) 预测了长期的心血管事件. 较高的aPP表明风险增加,为高风险患者的风险评估提供了有价值的工具.
科学领域:
- 心脏病学 心脏病学
- 血管医学 血管医学
- 临床风险评估临床风险评估
背景情况:
- 侵袭性静脉内压测量是黄金标准,但对于常规使用来说并不实用.
- 大动脉脉压 (aPP) 是一个潜在的非侵入性标志物,但其预后价值需要进一步调查.
- 本研究侧重于在接受侵入性冠状动脉血管造影 (ICA) 的患者中侵入性测量aPP的预后意义.
研究的目的:
- 为了评估入侵测量的大动脉脉压 (aPP) 的预后值.
- 确定aPP是否可以预测侵袭性冠状动脉血管学 (ICA) 患者的主要不良心血管事件 (MACE).
- 评估aPP作为高风险心血管人口中的风险分层工具的实用性.
主要方法:
- 预计将有1110名患者接受ICA治疗 (平均年龄65岁,35.5%为女性).
- 在ICA之前,使用尾导管侵入性测量了大动脉压力.
- 主要不良心血管事件 (MACE) 在6.3年的中位随访期间被跟踪.
主要成果:
- 在随访期间,共有153个MACE (13.8%) 发生.
- 与没有MACE的患者相比,MACE患者的aPP (83.0 ± 25.3 mmHg) 显着更高 (62.9 ± 18.1 mmHg;P < 0.001).
- 较高的aPP (≥78 mmHg) 与MACE风险增加有关 (日志级P < 0.001),并且在调整后,每增加10 mmHg的aPP将MACE风险增加68% (HR 1.68;P < 0.001).
结论:
- 侵入性测量的aPP是接受ICA的患者长期心血管结果的强大和独立预测器.
- 对于这个患者群体,aPP可以作为现有风险评估策略的宝贵补充.
- 这些发现强调了aPP在管理高风险心血管患者中的临床相关性.
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