读性患者的鼻内:首次在人类中用于预防反射发作
Matthias J Koepp1,2, Kai-Nicolas Poppert3, Thomas Felder4
1Department of Neurology, National Hospital for Neurology and Neurosurgery, Queens Square, London, UK.
Annals of neurology
|December 29, 2025
概括
鼻内塞尔特拉塞坦 (SEL) 为患者提供了快速的发作预防. 一次剂量延迟了发作,而两次剂量完全预防了阅读诱导的发作,显示出作为非二治疗的前景.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 反射发作,特别是阅读诱导的发作,尽管接受了标准的抗药物治疗,但仍可能持续存在.
- 列维 (3000毫克/天) 对一个经历阅读诱导的焦点并保持意识的患者来说是不够的.
研究的目的:
- 评估内选择 (SEL) 对急性预防反射发作的疗效和药理动力学.
- 为了研究鼻内SEL对发作和脑电图 (EEG) 活动在患者的影响.
主要方法:
- 首次给人注射鼻腔塞尔特拉塞坦 (30毫克) 给患有难治性读数诱导的患者.
- 药物动力学评估显示血清可检测性在2分钟内.
- 脑电图和磁脑图 (MEG) 监测以评估活动和传播.
- 在安慰剂和SEL管理之间的发作和尖峰频率的比较.
主要成果:
- 内SEL在2分钟内被检测到血清中.
- 内SEL的30毫克剂量延迟了发作发作时间,从刺激后的1:56 (安慰剂) 到4:17分钟.
- 第二次30毫克的剂量完全防止了阅读25分钟的发作.
- 脑电图峰值频率因剂量而有所下降 (3.1/分钟至1.6/分钟),在MEG上观察到峰值传播的减少.
结论:
- 鼻腔内塞尔特拉塞坦证明了快速有效的急性发作预防反射性发作.
- 在急性发作管理中,SEL显示出作为非二胺替代品的潜力.
- 研究结果提供了反射发作的动态和鼻内注射的实用性.
相关概念视频
Antiepileptic Drugs: Sodium Channel Blockers
1.5K
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
1.5K
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
790
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
790
Antiepileptic Drugs: Potassium Channel Activators
590
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
590
Antiepileptic Drugs: Glutamate Antagonists
853
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
853
Antiepileptic Drugs: GABAergic Pathway Potentiators
1.1K
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
1.1K
Epilepsy and Seizures: Overview
1.1K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.1K


