Jove
Visualize
联系我们

相关概念视频

Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

2.9K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
2.9K
Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists01:28

Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists

890
Histamine H2 receptors, which are intricately located on the basolateral membrane of parietal cells, play a crucial role in modulating gastric acid secretion. When released from enterochromaffin-like cells, histamine engages H2 receptors, initiating the cyclic AMP (cAMP) pathway. In this pathway, adenylyl cyclase converts ATP into cAMP, elevating intracellular cAMP levels. The activation of protein kinase A follows, stimulating the proton pump. This stimulation prompts the secretion of hydrogen...
890
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.7K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.7K
Upper Respiratory Drugs: First and Second-Generation Antihistamines01:15

Upper Respiratory Drugs: First and Second-Generation Antihistamines

990
Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
990
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers01:24

Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers

1.4K
Adrenergic stimulation generally impacts cardiac rate and rhythm. Specifically, stimulation of the β-adrenoceptors triggers an increase in intracellular calcium ion influx and pacemaker currents, which may cause arrhythmias. Catecholamines like adrenaline also demonstrate β2-adrenoceptor-mediated hypokalemia, impacting cardiac action potential and disrupting the normal cardiac rhythm. Class II antiarrhythmic drugs are β-adrenoceptor antagonists or β-blockers, which...
1.4K
Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

1.6K
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
1.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

GLP-1 Receptor Agonist Effect on Disease Severity in Idiopathic Subglottic Stenosis.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same author

Idiopathic Subglottic Stenosis in Pregnancy: A Case-Control Study of Management and Maternal Safety.

The Laryngoscope·2026
Same author

Diagnosis and Treatment of Refractory Chronic Cough: An American Broncho-Esophagological Association Expert Consensus Statement.

The Laryngoscope·2026
Same author

Effects of Mesenchymal Stem Cell-Derived Exosomes on Lung Inflammation in a Murine Aspiration Model.

The Laryngoscope·2026
Same author

Infracordal Stenosis: A Glucocorticoid-Responsive Subtype of Autoimmune Laryngotracheal Stenosis.

The Laryngoscope·2026
Same author

Evaluation of Veterinary Prescription of Gastroprotectants in Dogs in Spain.

Veterinary sciences·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jan 7, 2026

An Ex vivo Mast Cell Degranulation Assay using Crude Peritoneal Exudate Cells and Natural Antigen Stimulation
08:25

An Ex vivo Mast Cell Degranulation Assay using Crude Peritoneal Exudate Cells and Natural Antigen Stimulation

Published on: April 27, 2021

2.6K

基因组二受体对抗剂 塔基菲拉克斯:一个范围审查

James H Clark1, Zilla Hussain2, Lee Akst1

  • 1Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

The Laryngoscope
|December 29, 2025
PubMed
概括

基因组二受体对抗剂 (H2RAs) 由于分泌突变而迅速丧失有效性,到第3天显著减少. 这种减弱的效果,高达27.5%,表明H2RAs对于频繁的GERD管理不是理想的.

关键词:
格尔德 (GERD) 是一个很好的朋友.塔基菲拉克西斯 (Tachyphylaxis) 是一种表达时间的方法.组胺2受体对手 组胺2受体对手

更多相关视频

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.2K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.2K

相关实验视频

Last Updated: Jan 7, 2026

An Ex vivo Mast Cell Degranulation Assay using Crude Peritoneal Exudate Cells and Natural Antigen Stimulation
08:25

An Ex vivo Mast Cell Degranulation Assay using Crude Peritoneal Exudate Cells and Natural Antigen Stimulation

Published on: April 27, 2021

2.6K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.2K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.2K

科学领域:

  • 胃肠病学 胃肠病学
  • 药理学 药理学是指药理学的学科.
  • 临床医学 临床医学

背景情况:

  • 组胺2-受体对抗剂 (H2RAs) 通常用于胃食道逆流性疾病 (GERD).
  • 药物疗效在重复剂量下迅速下降的太基法力学,经常在H2RA中观察到,但对其了解甚少.
  • 了解H2RA分泌法对于优化GERD治疗策略至关重要.

研究的目的:

  • 对重复剂量的H2RA疗效下降进行范围审查.
  • 为了研究H2RA高血压的机制,影响和管理.
  • 评估H2RA高血压在GERD管理中的临床影响.

主要方法:

  • 在主要数据库 (PubMed,Embase,Scopus,Web of Science,Cochrane) 中按照PRISMA-ScR指南进行系统的文献搜索.
  • 由两个独立的审查员进行数据提取,重点关注机制,影响和管理策略.
  • 包括研究研究H2RA疗效和GERD患者的轻血症.

主要成果:

  • 最初,H2RAs将胃内pH值> 4从8%提高到38%.
  • 太基法拉克西开始于第二天,有效性在第三天下降11.2%,在第15天下降20.3%.
  • 质子抑制剂 (PPI) 在14天后保持胃内pH大于4的时间为63%而没有观察到太基.

结论:

  • 太基症是所有H2RA中记录良好的现象,导致绝对疗效降低高达25%.
  • 确切的驱动H2RA高提菲拉克斯的机制尚不清楚.
  • H2RAs不应该成为频繁的GERD的第一线治疗方法,也不应该经常添加到质子抑制剂治疗中.