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Updated: Jan 7, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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致病性Gαo突变驱动GNAO1脑病变中的主导GPCR合.

Yonika A Larasati1, Camille Rabesahala de Meritens1, Miriam Stoeber2

  • 1Translational Research Center in Oncohaematology, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|December 29, 2025
PubMed
概括

在GNAO1的突变导致神经发育障碍,通过破坏Gαo蛋白与G蛋白结合受体 (GPCRs) 的相互作用. 严重的变异会损害受体功能,突显出一个关键的疾病机制.

关键词:
与G蛋白结合受体 (GPCRs) 相关的受体一个GNAO1一个GNAO1澳门银河娱乐场 澳门银河娱乐场 澳门银河娱乐场双分子光补充 (BiFC) 方法迪斯托尼亚 (Dystonia) 是一种精神疾病.是一种.异构三元的G蛋白质.运动障碍 运动障碍神经发育障碍 神经发育障碍

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