Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.8K
Phylogenetic Trees03:21

Phylogenetic Trees

49.1K
Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
49.1K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.9K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.9K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

3.4K
3.4K
Phylogeny01:23

Phylogeny

56.6K
Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.
56.6K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

541
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
541

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

BetaDescribe: Providing rich descriptions from protein sequences.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

CLADES - Contrastive Learning Augmented DifferEntial Splicing with Orthologous Positive Pairs.

bioRxiv : the preprint server for biology·2026
Same author

The role of plant polyploidy in the structure of plant-pollinator communities.

Frontiers in plant science·2026
Same author

Comparative metagenomics using pan-metagenomic graphs.

bioRxiv : the preprint server for biology·2025
Same author

Transcriptomic Plasticity Is a Hallmark of Metastatic Pancreatic Cancer.

Cancer research·2025
Same author

Distributional bias compromises leave-one-out cross-validation.

Science advances·2025
Same journal

conMItion: an R package adjusting confounding factors for associations in multi-omics.

Bioinformatics (Oxford, England)·2026
Same journal

SpaMFG: a Spatial Multi-omics Integration Method based on Feature Grouping.

Bioinformatics (Oxford, England)·2026
Same journal

CSCN: Inference of Cell-Specific Causal Networks Using Single-Cell RNA-Seq Data.

Bioinformatics (Oxford, England)·2026
Same journal

Sparse CCA-Based Mediation Analysis with High-Dimensional Exposures and Mediators.

Bioinformatics (Oxford, England)·2026
Same journal

Enhancing Cross-Context Generalization in Drug Perturbation Prediction with a Multimodal Conditional Diffusion Framework.

Bioinformatics (Oxford, England)·2026
Same journal

Primer Design through Submodular Function Estimation.

Bioinformatics (Oxford, England)·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

36.0K

有效的算法用于模拟沿着家族遗传树的序列.

Elya Wygoda1, Asher Moshe1, Nimrod Serok1

  • 1The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.

Bioinformatics (Oxford, England)
|December 29, 2025
PubMed
概括
此摘要是机器生成的。

有效的序列模拟加速了分子进化研究. 新的算法优化了插入/删除 (indel) 事件的处理,使得进化模型能够更快地进行遗传学分析和参数推断.

更多相关视频

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

16.4K
Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
10:18

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing

Published on: October 16, 2018

12.6K

相关实验视频

Last Updated: Jan 7, 2026

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

36.0K
Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

16.4K
Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
10:18

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing

Published on: October 16, 2018

12.6K

科学领域:

  • 计算生物学 计算生物学
  • 分子进化分子进化
  • 生物信息学是一种生物信息学.

背景情况:

  • 在家族遗传树上的序列模拟对于基准算法和推断进化模型至关重要.
  • 大致贝叶斯计算 (ABC) 方法需要广泛的模拟数据来实现复杂的进化模型.
  • 计算高效的序列模拟器对于推进分子进化研究至关重要.

研究的目的:

  • 开发和研究用于模拟沿着家族遗传树的序列的快速算法.
  • 通过优化插入和删除 (indel) 事件的处理来加快模拟过程.
  • 将一个高效的模拟器集成到基于ABC的算法中,用于推断indel模型参数.

主要方法:

  • 开发和评估数据结构,以有效地存储沿着家族遗传树沿线发生的事件.
  • 将新型模拟算法的性能与天真方法进行了比较.
  • 将高效的模拟器集成到一个近似贝叶斯计算 (ABC) 框架中.

主要成果:

  • 对于indel事件的高效数据结构显著加快了沿着家族遗传树的序列模拟.
  • 开发的模拟器显示了与天真方法相比的实质性速度改进.
  • 集成模拟器成功地被应用到使用ABC的Chiroptera中研究indel动力学.

结论:

  • 优化处理indel事件是加速植物遗传序列模拟的关键.
  • 新的高效模拟器提高了计算密集型遗传学分析的可行性.
  • 这项工作为推断indel模型参数和研究进化动态提供了有价值的工具.