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Updated: Jun 20, 2026

Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry
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Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry

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工程反应接口可实现多种 thiols 的质谱成像,用于解码 PFOS 诱导的 redox 失调

Hongmei Xu1,2, Thomas Ka-Yam Lam2, Simin Zhang2

  • 1Institute of Environmental Science, Shanxi University, Taiyuan 030006, China.

Analytical chemistry
|December 29, 2025
PubMed
概括

这项研究引入了一种使用反应接口可视化组织中的硫醇的新方法,提高了氧化应激研究的灵敏度和空间精度. 该技术成功地绘制了硫醇分布图,并揭示了污染物暴露后脏氧化还原变化.

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相关概念视频

Preparation and Reactions of Thiols02:33

Preparation and Reactions of Thiols

Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
Redox Titration: Overview01:21

Redox Titration: Overview

Redox titration is a chemical analysis technique used to determine the concentration of an unknown substance by measuring the electron transfer in a redox (reduction-oxidation) reaction. The process involves gradually adding a titrant with a known concentration of an oxidizing or reducing agent, to the analyte, the solution with an unknown concentration, until reaching the endpoint, which indicates the completion of the reaction between the two substances. Ensuring the analyte is in a single...