开发和优化用于局部治疗的亚西化物联合晶体载荷的皮肤贴片
Suhas Shivaji Siddheshwar1, Omkar Atkare2, Arti Changdev Ghorpade2
1Department of Pharmaceutics, Pravara Rural College of Pharmacy, Loni, Maharashtra, India. drssiddheshwar@gmail.com.
Naunyn-Schmiedeberg's archives of pharmacology
|December 29, 2025
概括
这项研究开发了一种优化透皮贴片,其中含有亚西化物联合晶体,以增强伤口愈合. 非刺激性贴片表明药物释放持续,有效性与标准治疗相比,改善了患者的便利性.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 皮肤病学 皮肤病学
背景情况:
- 亚西化物是治疗伤口的有前途的化合物,但其局部应用因溶解性差和机械性能不佳而受到限制.
- 透皮贴片提供了一个非侵入性的药物输送系统,用于持续的局部治疗.
研究的目的:
- 开发和优化一种基于水凝的透皮贴片,其中包含亚化合晶.
- 为了增强亚西胺的可溶性,机械性质,并实现持续释放,以进行有效的伤口管理.
- 评估开发过皮贴的物理化学,生物和稳定性性能.
主要方法:
- 亚洲化物联合晶体是通过用酸蒸发溶剂来制备的.
- 使用HPMC K100M和PEG 400来制定水凝皮肤贴片.
- 一个3^2的全因数设计优化了辅助剂度,随后进行了全面的物理化学,体外和体内评估.
主要成果:
- 通过DSC和FTIR证实了共晶的形成,显示了更好的特性.
- 优化的补丁 (F2) 显示了理想的厚度 (0.36毫米) 和折叠耐久性 (216) 与低误差.
- 在12小时内体外释放量为95.2%,遵循希克森-克劳尔动力学和Fickian扩散.
- 在体内研究表明没有皮肤刺激和伤口收缩95.0%的第9天.
- 加速稳定性研究表明,3个月的时间内变化很小.
结论:
- 开发的亚洲化物共晶透皮贴片是一种有前途的,无刺激的伤口护理系统.
- 该贴片提供持续的药物释放,增强治愈效率,并改善患者的服药性.
- 需要进一步的药理动力学和翻译性研究来探索其临床潜力.
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