VPS9D1-AS1:在人类恶性瘤中具有关键的瘤长非编码RNA
Bing Wang1, Huaming Hu2, Tingting Yu3
1Department of Respiratory and Critical Medicine, Jingmen Hospital of Traditional Chinese Medicine, Jingmen, 448000, People's Republic of China.
概括
长非编码RNAVPS9D1-AS1 (VPS9D1-AS1) 通过影响基因表达和信号通路,促进癌症的进展. 高的VPS9D1-AS1水平与晚期癌症和患者的不良结果相关,这表明其作为生物标志物的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 长非编码RNAs (lncRNAs) 是癌症发展的关键调节者.
- VPS9D1反感RNA 1 (VPS9D1-AS1),也称为MYU,在各种瘤中被上调.
- VPS9D1-AS1位于16q24.3.3染色体上
研究的目的:
- 审查VPS9D1-AS1在恶性瘤中的作用和分子机制.
- 评估VPS9D1-AS1在瘤学中的临床意义和潜在应用.
- 突出VPS9D1-AS1作为潜在的诊断生物标志物和治疗目标.
主要方法:
- 在癌症中对VPS9D1-AS1的研究的文献综述.
- 分子机制的分析,包括基因调节,miRNA海绵化和通路调节 (Wnt/β-catenin,TGF-β/ISG,PI3K/AKT).
- 对VPS9D1-AS1表达与瘤大小,阶段,转移和预后等临床参数的相关性分析.
主要成果:
- VPS9D1-AS1促进癌细胞的增殖,入侵,迁移和上皮-介质细胞过渡 (EMT).
- 高VPS9D1-AS1表达与较大的瘤体积,晚期临床阶段,转移增加和预后较差有关.
- VPS9D1-AS1通过多种分子相互作用作为癌症促进剂.
结论:
- VPS9D1-AS1在各种癌症中起着显著的致癌作用.
- VPS9D1-AS1表达水平是瘤进展和患者结果的有价值指标.
- VPS9D1-AS1作为癌症治疗的诊断生物标志物和治疗点具有有前途的潜力.
相关概念视频
lncRNA - Long Non-coding RNAs
9.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.7K
lncRNA - Long Non-coding RNAs
3.4K
3.4K
Rous Sarcoma Virus (RSV) and Cancer
6.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.1K
Cancer-Critical Genes I: Proto-oncogenes
11.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.0K
Non-LTR Retrotransposons
13.1K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
13.1K
Abnormal Proliferation
5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K

