创建和验证测量力度GERD得分,以预测阳性反流检测 (胃食道反流病)
1Department of Gastroenterology, Arihant Hospital and Research Centre, 283-A Gumasta Nagar, Indore, 452 009, India. mayank4670@rediffmail.com.
概括
一个新的Manometry GERD评分 (MGS) 有效地预测胃食道逆流症 (GERD) 使用高分辨率食道测量 (HREM) 参数. 这一分数有助于诊断GERD,改善患者护理.
科学领域:
- 胃肠病学 胃肠病学
- 食道生理学 食道生理学
- 诊断工具 诊断工具
背景情况:
- 胃食道逆流性疾病 (GERD) 诊断传统上依赖于内镜检查,高分辨率食道测量 (HREM) 和24小时pH测试.
- 准确的表型定型对于有效的GERD管理至关重要.
研究的目的:
- 为了确定与阳性反流试验相关的HREM参数.
- 开发和验证一个Manometry GERD评分 (MGS) 用于预测阳性反流试验.
主要方法:
- 一项前性研究,包括18岁以上的患者转诊HREM和24小时pH测试.
- 确定了HREM参数,可以显著区分阳性和阴性反流试验,并分配权重点来创建MGS.
- 经过前性验证的MGS,分析了灵敏度,特异性,PPV,NPV和AUROC.
主要成果:
- 异常多重快速吞 (MRS),食管胃结 (EGJ) 收缩整体 (CI) <39 mmHg,以及EGJ形态类型2/3在阳性反流患者中更为常见.
- 最多获得5分的MGS显示了0.85.8的AUROC.
- 一个MGS切线>3.5显示了83.1%的灵敏度和80.2%的特异性来检测正反流.
结论:
- 异常的MRS,EGJ-CI<39 mmHg和EGJ形态类型2/3是正反流的关键HREM指标.
- 人口测量GERD评分 (MGS) 是一个有价值的工具,用于预测GERD患者的阳性反流检测.
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