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Updated: Jan 7, 2026

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在eIF5和eIF2β中的翻译启动忠实性缺陷突变对识别UUG启动符号的序列上下文具有明显的敏感性

Anup Kumar Ram1,2,3, Tanaya Kole1,2, Pankaj V Alone4,5

  • 1School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, P.O. Jatni, Khurda, 752050, India.

Biochemical genetics
|December 29, 2025
PubMed
概括

突变的酵母蛋白 (eIF5 ((G31R) 和eIF2β ((S264Y)) 可以在UUG编码子上启动翻译. 序列上下文,特别是 -3 和 -1 位置的 purin,影响了这种近同源起始编码子选择.

关键词:
序列上下文 序列上下文开始编码子选择.它的表型就是表型.开始翻译开始翻译如果eIF2ββeIF5 eIF5 eIF5 eIF5 eIF5 eIF5 eIF5 eIF5 eIF5 eIF5

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