Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.9K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.9K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.4K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.4K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.8K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.8K
Hematopoiesis01:21

Hematopoiesis

8.5K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.5K
Lineage Commitment01:21

Lineage Commitment

4.0K
Commitment is the  process whereby stem cells:
4.0K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.6K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Enhanced postharvest protection of cherry tomatoes by a fully bio-based quasi-mixed matrix membrane (quasi-MMM) with dual-mechanism integration of organic filler.

Food chemistry: X·2026
Same author

Multi-kingdom gut microbiota analysis identifies bacterial-viral association in multiple myeloma.

Frontiers in microbiology·2026
Same author

SLC40A1 (iron transporter): mechanistic regulation, role in disease pathogenesis, and prospects for targeted therapy.

Frontiers in cell and developmental biology·2026
Same author

Tailoring a nanozyme-based electronic tongue for coffee flavor evaluation: A rapid and accurate identification.

Food chemistry·2026
Same author

LC3B as a potential serum biomarker for screening high-risk neuroblastoma patients.

Acta neurologica Belgica·2026
Same author

Repaint High-Density Surface Electromyography Signal Using Denoising Diffusion Probabilistic Model.

IEEE transactions on bio-medical engineering·2025

相关实验视频

Updated: Jan 7, 2026

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging
09:10

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

3.6K

关于介质干细胞如何调节造血干细胞行为的研究进展.

YiHui Zhao1, JianXia He2

  • 1Department of Hematology, Shanxi Provincial People's Hospital, Tai Yuan, 030000, China.

Molecular biology reports
|December 29, 2025
PubMed
概括

介酶干细胞 (MSC) 和它们的细胞外囊泡 (EV) 对于调节其位中的造血干细胞 (HSC) 至关重要. 了解MSC-HSC相互作用为造血干细胞移植 (HSCT) 和治疗骨髓疾病提供了新的策略.

关键词:
骨髓的利基是骨髓中的一个.血液形成 血液形成 血液形成造血干细胞移植 造血干细胞移植造血干细胞 造血干细胞 造血干细胞机理机制 机理机制介质细胞干细胞 介质细胞干细胞

更多相关视频

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs
06:20

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Published on: December 24, 2015

12.8K
Purification, Expansion, and Flow Cytometry-Based Phenotyping of Mouse Derived Bone Marrow Mesenchymal Stem Cells
05:10

Purification, Expansion, and Flow Cytometry-Based Phenotyping of Mouse Derived Bone Marrow Mesenchymal Stem Cells

Published on: July 11, 2025

973

相关实验视频

Last Updated: Jan 7, 2026

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging
09:10

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

3.6K
Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs
06:20

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Published on: December 24, 2015

12.8K
Purification, Expansion, and Flow Cytometry-Based Phenotyping of Mouse Derived Bone Marrow Mesenchymal Stem Cells
05:10

Purification, Expansion, and Flow Cytometry-Based Phenotyping of Mouse Derived Bone Marrow Mesenchymal Stem Cells

Published on: July 11, 2025

973

科学领域:

  • 血液学 血液学 血液学
  • 干细胞生物学 干细胞生物学
  • 细胞疗法细胞疗法

背景情况:

  • 介酶干细胞 (MSC) 是血造干细胞 (HSC) 利基的关键组成部分,影响HSC命运.
  • 在骨髓微环境中,MSCs对于HSC的生存,增殖,迁移和分化至关重要.
  • 来自MSC的细胞外囊泡 (EVs) 是一个重要的细胞间通信通路,调节HSCs.

研究的目的:

  • 审查MSCs调节HSCs的机制的研究进展.
  • 阐明MSC-HSC相互作用在维持造血平衡中的作用.
  • 探索MSCs和EVs作为血液造血干细胞移植 (HSCT) 的辅助疗法的潜力.

主要方法:

  • 对研究MSC-HSC相互作用的文献综述.
  • 分析细胞间通讯通路,包括细胞接触,可溶性因子和EVs.
  • 检查调节MSC-HSC通信的信号通路和基因表达.

主要成果:

  • MSCs通过直接接触,分泌因素和EVs来控制HSC的命运.
  • 由MSC衍生的EV携带影响HSC行为的生物活性分子.
  • MSCs和HSCs之间的细胞间通信是复杂的,涉及不同的信号通路.

结论:

  • 对MSC-HSC相互作用网络的更深入的理解对于维持造血平衡至关重要.
  • 优化HSCT和开发骨髓衰竭疾病的治疗方法可以从MSC-HSC监管的洞察中受益.
  • MSC及其EV作为治疗HSCT和相关疾病的治疗工具具有前景.