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切除食道腺癌患者骨质疏松症的预后影响:一项回顾性研究
Alberto Aiolfi1, Davide Bona2, Gianluca Bonitta2
1Division of General Surgery, Department of Biomedical Science for Health, I.R.C.C.S. Ospedale Galeazzi-Sant'Ambrogio, University of Milan, Milan, Italy. alberto.aiolfi86@gmail.com.
Annals of surgical oncology
|December 29, 2025
概括
骨质疏松症是一种骨密度低的疾病,与食道腺癌患者的生存率降低有关. 这项研究发现,骨质疏松症独立预测较差的结果,包括增加的肺炎和死亡风险.
科学领域:
- 在瘤学瘤学.
- 骨的新陈代谢 骨的新陈代谢
- 外科手术的结果
背景情况:
- 骨质疏松症与食道状细胞癌的脆弱性和糟糕的生存率有关.
- 骨质疏松症对食道腺癌存活率的影响尚不清楚.
研究的目的:
- 评估患有可切除食道腺癌的患者骨质疏松症和长期存活率之间的关联.
主要方法:
- 对338名患有可切除的Siewert I-II食道腺癌的患者进行了回顾性研究,这些患者接受了艾佛-路易斯食道切除术.
- 骨质疏松症是由手术前CT扫描骨矿物密度 (<160霍恩斯菲尔德单位) 在L1脊椎定义的.
主要成果:
- 骨质疏松症的患病率为27.8%,与较高的解管泄漏率,肺炎和90天死亡率相关.
- 骨质疏松症独立预测了肺炎和90天死亡率.
- 患有骨质疏松症的患者显示60个月整体生存 (OS) 和无病生存 (DFS) 概率显著降低.
结论:
- 骨质疏松症影响了近三分之一的食道腺癌患者.
- 骨质疏松症是术后并发症,90天死亡率和长期减少的OS和DFS的独立预测因素.
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