中年和老年日本男性阿尔茨海默病的血生物标志物:基于人口的横截面研究
Masaki Nakano1, Keiko Kondo2, Kengo Ishiki3
1Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga, Japan.
Journal of Alzheimer's disease : JAD
|December 29, 2025
概括
阿尔茨海默病 (AD) 的血液生物标志物受到年龄和功能的影响. 总 (T-tau) 和化 (P-tau181) 的较高水平与男性早期认知能力下降相关.
科学领域:
- 神经学 神经学
- 生物化学 生物化学
- 老年学是一门学科.
背景情况:
- 阿尔茨海默病 (AD) 神经病理学的基于血液的生物标志物的诊断价值已在有症状的个体中确定.
- 对阿尔茨海默病的可靠临床前诊断方法仍然不足.
- 混变量可能会模糊生物标志物的解释.
研究的目的:
- 为了确定影响血AD生物标志物的混变量.
- 检查生物标志物和生理指数 (年龄,功能,认知功能) 之间的关联.
- 为了调查这些协会在日本男性从一般人群.
主要方法:
- 从845名日本男性 (>40岁) 的血样本中分析了粉样蛋白-β (Aβ40,Aβ42),总 (T-tau),酸化 (P-tau181) 和神经纤维光链 (NfL).
- 使用认知能力查仪器 (CASI) 评估认知功能.
- 使用线性回归模型来评估关联,并对混因素进行调整.
主要成果:
- 血Aβ40,Aβ42,T-tau,P-tau181,NfL和P-tau181/T-tau随着年龄的增长和估计膜过率 (eGFR) 的下降而增加.
- 随着年龄的增长,Aβ42/Aβ40比率下降.
- 较高的T-tau和P-tau181与较低的CASI分数有关;较低的Aβ42/Aβ40比率表明临床前的tau病理和神经退行.
结论:
- 血AD生物标志物受到年龄和干净度的显著影响.
- 升高的T-tau和P-tau181与临床前认知障碍有关.
- 较低的Aβ42/Aβ40比率可能表明无症状的tau病理和神经退行.
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