婴儿母乳养和发育结果与产前大麻暴露:一个回顾性队列研究
Nichole Nidey1, Jennifer M McAllister2, Mishka Terplan3
1Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa, USA.
概括
在子宫内接触大麻的母乳养婴儿与未母乳养婴儿相比,没有表现出不同的发育结果. 这些发现支持目前关于大麻使用和母乳养安全的指导方针.
科学领域:
- 围产期健康 围产期健康
- 发育儿科 发育儿科
- 大麻研究 大麻研究 大麻研究
背景情况:
- 人母乳对婴儿健康至关重要,但母亲吸食大麻引起了人们对母乳养的担忧.
- 产前接触大麻可能会影响婴儿的发育,需要对母乳养的作用进行研究.
研究的目的:
- 调查母乳养与婴儿与产前大麻暴露的发育结果之间的关联.
- 为使用大麻的母亲提供有关母乳养实践的临床指导.
主要方法:
- 使用区域围产期数据库进行回顾性队列研究.
- 包括在分娩时为大麻的母亲尿液药物测试呈阳性的婴儿 (n=1,520).
- 通过ICD-9/10代码评估发育迟缓;根据出生证明评估母乳养状态;使用后勤回归.
主要成果:
- 在1520名婴儿中,46%是母乳养的. 未经调整的分析显示,非母乳养婴儿的发育迟缓的几率更高 (OR: 1.32).
- 经过对母亲的烟草使用,早产和出生年份进行调整后,不母乳养和发育迟缓之间的关联在统计学上并不显著 (OR:1.24).
结论:
- 在母乳养和非母乳养的婴儿与产前大麻暴露之间,发育结果没有差异.
- 这些发现支持当前的专业指导,即大麻使用不是母乳养的禁忌.
- 需要对更大的队列进行进一步的研究,以探索母乳养在孕产妇使用大麻环境中的保护作用和安全性.
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